Photo by Lee Pellegrini
涩里番下载 researchers have developed a new type of 鈥渃ross-coupling鈥� chemical reaction, building on a Nobel Prize-winning technique that is one of the most sophisticated tools available to research chemists, .
Transition metal catalyzed cross-coupling reactions were the subject of the 2010 Nobel Prize in chemistry. A key component of that novel approach 鈥� known as Suzuki-Miyaura coupling 鈥� connects two types of reactants, including one electron donor and one electron acceptor. The team鈥檚 new approach adds a third reactant.
James P. Morken, the Louise and James Vanderslice and Family Professor of Chemistry, and his team report using transition metals to develop an alternative cross-coupling process that merges two electron donors while they react with the electron acceptor. The resulting 鈥渃onjunctive鈥� reaction takes place efficiently and offers a high degree of selectivity, according to Morken and the co-authors of the report 鈥淐atalytic Conjunctive Cross-Coupling Enabled by Metal-Induced Metallate Rearrangement.鈥�
鈥淥ur first significant step was determining that transition metals could facilitate the merger of two organic reactants in a manner commonly observed for other non-metallic chemical reagents,鈥� said Morken. 鈥淥nce the team made this connection, then we narrowed our focus to consider ways in which catalysis might be achieved.鈥�
Other members of the team included graduate students Liang Zhang, Gabriel J. Lovinger, Emma K. Edelstein, Adam A. Szymaniak and Matteo P. Chierchia.
In a companion 鈥減erspective鈥� piece in Science, chemists James W.B. Fyfe and Alan J.B. Watson called the team鈥檚 findings one of the few advances on the Suzuki-Miyaura method since its initial discovery nearly 40 years ago.
The Morken lab鈥檚 advance is 鈥渙f enormous potential value in terms of the development of new catalytic transformations, paving the way for a new generation of exciting research,鈥� according to Fyfe and Watson, of the University of Strathclyde in Glasgow, Scotland. [The piece is online at ]
In a field as widely studied as transition metals cross-coupling, Morken said the researchers were surprised to uncover a new variation on the ground-breaking catalytic method. The team鈥檚 early research shows that the new type of reaction can be efficient and selective, two characteristics prized by the researchers who use these types of catalysts, Morken said.
The team鈥檚 focus is now on finding abundant and cost-effective metal compounds to enable the three-reactant cross-coupling, he said.
鈥淥ur team is addressing the limitations found in the early-stage development and I think in the long-term that this mode of catalysis will have an impact on the way organic compounds are manufactured, most likely those used in the pharmaceutical industry. If the underlying reactivity can be used in other catalytic chemical processes, then that should open up a broad new collection of chemical reactions that will be of use in chemical manufacture.鈥�
Ed Hayward | Office of News & Public Affairs